Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

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Authors

PERNICOVÁ Zuzana SLÁBÁKOVÁ Eva KHARAISHVILI Gvantsa BOUCHAL Jan KRÁL Milan KUNICKÁ Zuzana MACHALA Miroslav KOZUBÍK Alois SOUČEK Karel

Year of publication 2011
Type Article in Periodical
Magazine / Source Neoplasia
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf
Doi http://dx.doi.org/10.1593/neo.11182
Field Genetics and molecular biology
Keywords CELLULAR SENESCENCE; IN-VIVO; DEPRIVATION THERAPY; SECRETORY PHENOTYPE; EPITHELIAL-CELLS; TUMORIGENESIS; FIBROBLASTS; EXPRESSION; GROWTH; PROLIFERATION
Description Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We propose that ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells.
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