Využití in vitro biotestů pro hodnocení kontaminace vodního prostředí AhR-aktivními látkami.

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Title in English	USE OF IN VITRO BIOASSAYS TO EVALUATE CONTAMINATION OF AQUATIC ENVIRONMENT WITH AhR-ACTIVE COMPOUNDS
Authors	MACÍKOVÁ Petra GIESY J. HILSCHEROVÁ Klára
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Bulletin VÚRH Vodňany
MU Faculty or unit	Faculty of Science
Citation
Field	Environment influence on health
Keywords	AhR-dependent toxicity; river ecosystem; passive sampling; in vitro assays
Description	The aquatic environment is contaminated with many types of chemical compounds that can be dissolved in water or bound to solid particles and in sediments. In complex mixtures is very difficult to estimate their toxic potential. Many types of hydrophobic persistent pollutants are able to activate arylhydrocarbon receptor (AhR) that might have negative consequences for organisms’ health. Suitable tools to assess AhR-active (dioxin-like) compounds in aquatic samples are in vitro bioassays in combination with chemical analysis.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R. Centrum pro výzkum toxických látek v prostředí