Project information
Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology
- Project Identification
- KJB501620601
- Project Period
- 2/2006 - 12/2008
- Investor / Pogramme / Project type
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Academy of Sciences of the Czech Republic
- The research grant projects for juniors
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- RAGE, haplotype, promotor, diabetes
Formation of Advanced Glycation End-products (AGEs) and subsequent activation of the Receptor of AGEs (RAGE) represents one of the principal pathogenic mechanisms of hyperglycaemia-induced cell damage.
Publications
Total number of publications: 16
2007
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Haplotype-based association study between the region of 6p chromosome spanning the AGER - TNFA - LTA - NFKBIL1 - BAT1 and diabetic nephropathy
Year: 2007, type: Conference abstract
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Nutrient-gene interactions in diabetes - advanced glycation end products (AGEs)
Year: 2007, type: Conference abstract
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SNPs in adipokines - adiponectin and leptin - as risk factors for diabetic complications: evidence for a "double-hit" mechanism?
Year: 2007, type: Conference abstract
2006
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Haplotype analysis of the region of 6p chromosome spanning the AGER – TNFA – LTA – NFKBIL1 – BAT1 loci: Preliminary results of association study with diabetic nephropathy and retinopathy
Year: 2006, type: Conference abstract
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Increased plasma levels of sRAGE in patients with diabetic nephropathy
Year: 2006, type: Conference abstract
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Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy
Year: 2006, type: Conference abstract