Project information
Laboratory of Structure and Dynamics of Biomolecules
- Project Identification
- VS96095
- Project Period
- 7/1996 - 12/2000
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Support to University Research Programmes
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Keywords
- biomolecular structure and dynamics, structural biology, computer modeling, NMR spectroscopy, X-ray crystallography, oligonucleotides, peptides, proteins, carbohydrates, nucleotide-sugars
The subject of the proposal is to create Laboratory of Biomolecular Structure and Dynamics. An efficient scientific program is proposed, which will ensure that two recent large investment activities (the supercomputer project and the NMR instrument) will efficiently be used. The project is a combination of NMR spectroscopy, X-ray crystallography and computer modeling. The scientific goals include both methodoly development and its applications on biologically interesting molecules. The systems studied will include oligonucleotides, peptides, carbohydrates, nucleotide-sugars, and proteins. The strategical direction for high technology will be biodegradation in the environment.
Publications
Total number of publications: 27
1997
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(-)-Armepavine: Gradient-enhanced 2D-NMR study and X-ray crystal structure determination
Collection of Czechoslovak Chemical Communications, year: 1997, volume: 62, edition: 10
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(+)-Catechin: Benzoyl protection of OH groups and NMR study of Products
Chemical Papers, year: 1997, volume: 51, edition: 2
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Conformational Study of C2 Symmetrical Benzo[c]phenantridine Alkaloid Derivatives
Chemistry Letters, year: 1997, volume: 1997, edition: 4
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Gradient - enhanced HSQC experiments for phase-sensitive detection of multiple bond interactions.
Tetrahedron Letters, year: 1997, volume: 38, edition: 4
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Gradient-enhanced inverse-detected NMR techniques for determination of 1H-15N coupling constants in 2,2-dimethylpenta-3,4-dienal derivatives
Collection of Czechoslovak Chemical Communications, year: 1997, volume: 62, edition: 11
1996
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Determination of 15N chemical shifts and remote connectivities in selected alkaloids by gradient-enhanced inverse-detected NMR experiments
Molecules, year: 1996, volume: 1, edition: 1
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Determination of a Symmetrical Dimer Structure in Benzo[c]phenanthridine Alkaloids by Pulsed-Field-Gradient HMBC
Tetrahedron Letters, year: 1996, volume: 37, edition: 10