Project information
Vysoce efektivní systém založený na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako terapeutického cíle pro Alzheimerovu chorobu
(Alzheimer)
- Project Identification
- GA16-06106S
- Project Period
- 1/2016 - 12/2018
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
Hlavním cílem tohoto projektu je vývoj vysoce efektivního systému založeného na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako potenciálního terapeutického cíle pro léčbu Alzheimerovy choroby.
Publications
Total number of publications: 41
2023
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CYP2C19 and CYP3A4 activity is associated with survival in ticagrelor-treated patients after ST-elevation myocardial infarction
Year: 2023, type: Conference abstract
2020
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Online Enantioselective Capillary Electrophoretic Method for Screening Cytochrome P450 3A4 Inhibitors
Targeting Enzymes for Pharmaceutical Development: Methods and Protocols, edition: Vyd. 1., year: 2020, number of pages: 12 s.
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Screening of Beta-Secretase Inhibitors by Capillary Electrophoresis-Mass Spectrometry
Targeting Enzymes for Pharmaceutical Development: Methods and Protocols, edition: Vyd. 1, year: 2020, number of pages: 11 s.
2019
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Capillary electrophoresis-based approaches for the study of affinity interactions combined with various sensitive and non-traditional detection techniques
Electrophoresis, year: 2019, volume: 40, edition: 5, DOI
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Capillary electrophoresis-integrated immobilized enzyme reactor for kinetic and inhibition assays of beta-secretase as the Alzheimer's disease drug target
Journal of Separation Science, year: 2019, volume: 42, edition: 5, DOI
2018
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A label-free MALDI TOF MS-based method for studying the kinetics and inhibitor screening of the Alzheimer’s disease drug target beta-secretase
Analytical and Bioanalytical Chemistry, year: 2018, volume: 410, edition: 28, DOI
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An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors
Electrophoresis, year: 2018, volume: 2018, edition: 7, DOI
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Automating mixing of the sample for CE-FA by means of CE
Year: 2018, type: Conference abstract
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Capillary electrophoresis applications for study of β secretase as an Alzheimer’s disease target
Year: 2018, type: Appeared in Conference without Proceedings
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Capillary Electrophoretic Method with Fluorescence Detection as a Promising Tool for Screening of Beta-Secretase Inhibitors
Year: 2018, type: Conference abstract