Project information
Vysoce efektivní systém založený na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako terapeutického cíle pro Alzheimerovu chorobu
(Alzheimer)
- Project Identification
- GA16-06106S
- Project Period
- 1/2016 - 12/2018
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
Hlavním cílem tohoto projektu je vývoj vysoce efektivního systému založeného na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako potenciálního terapeutického cíle pro léčbu Alzheimerovy choroby.
Publications
Total number of publications: 41
2018
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CE-LIF method for β-secretase enzyme assays as a potential target treatment of Alzheimer's disease
Year: 2018, type: Conference abstract
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Development of Capillary Electrophoretic Method with Fluorescence Detection for Beta-Secretase Activity Assays with FRET-Labeled Substrate
Year: 2018, type: Conference abstract
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Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models
Drug Metabolism and Disposition, year: 2018, volume: 46, edition: 6, DOI
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Immobilized-enzyme reactors integrated with capillary electrophoresis for pharmaceutical research
Journal of Separation Science, year: 2018, volume: 41, edition: 1, DOI
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Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice
Biomedical Papers, Olomouc: Palacky University, year: 2018, volume: 162, edition: 1, DOI
2017
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A capillary electrophoresis-mass spectrometry based method for the screening of beta-secretase inhibitors as potential Alzheimer's disease therapeutics
Journal of Chromatography A, year: 2017, volume: 1487, edition: 3 March 2017, DOI
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An improved design to capture magnetic microparticles for in-line CE in a liquid based capillary coolant system
Year: 2017, type: Conference abstract
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Application of capillary electrophoresis for beta-secretase inhibitor screening - development and comparison of two on-line methods
Year: 2017, type:
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Application of CE-C4D for beta-secretase activity assay
Year: 2017, type: Conference abstract
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Application of off-line and on-line capillary electrophoretic methods for kinetic and inhibition studies of beta-secretase activity
Year: 2017, type: