Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 327
2022
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Structural and functional basis of mammalian microRNA biogenesis by Dicer
Molecular Cell, year: 2022, volume: 82, edition: 21, DOI
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Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds
Journal of Virology, year: 2022, volume: 96, edition: 17, DOI
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Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly
Communications Biology, year: 2022, volume: 5, edition: 1, DOI
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Synthesis of Glycoluril Dimers with the Ability to Form Polymeric Self-Associates in Water
Chemistry, year: 2022, volume: 4, edition: 3, DOI
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Tail proteins of phage SU10 reorganize into the nozzle for genome delivery
Nature Communications, year: 2022, volume: 13, edition: 1, DOI
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Technologies for drug discovery at CEITEC Biomolecular Interactions and Crystallization CF
Year: 2022, type:
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The essential cysteines in the CIPC motif of the thioredoxin-like Trypanosoma brucei MICOS subunit TbMic20 do not form an intramolecular disulfide bridge in vivo
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, year: 2022, volume: 248, edition: MAR, DOI
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The Highest Density of Phosphorylated Histone H1 Appeared in Prophase and Prometaphase in Parallel with Reduced H3K9me3, and HDAC1 Depletion Increased H1.2/H1.3 and H1.4 Serine 38 Phosphorylation
LIFE-BASEL, year: 2022, volume: 12, edition: 6, DOI
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The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux Carrier Harbors Hallmarks of an Intrinsically Disordered Protein
International Journal of Molecular Sciences, year: 2022, volume: 23, edition: 11, DOI
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The Pork Meat or the Environment of the Production Facility? The Effect of Individual Technological Steps on the Bacterial Contamination in Cooked Hams
MICROORGANISMS, year: 2022, volume: 10, edition: 6, DOI