Study and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1,2,3-selenadiazoles
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Chemical communications |
| MU Faculty or unit | |
| Citation | |
| web | http://pubs.rsc.org/en/Content/ArticleLanding/2016/CC/C6CC01789D#!divAbstract |
| Doi | http://dx.doi.org/10.1039/c6cc01789d |
| Field | Organic chemistry |
| Keywords | FREE CLICK CHEMISTRY; COPPERFREE CLICK; SELENIUM HETEROCYCLES; PHENYL AZIDE; PHOTOLYSIS; SELENADIAZOLE; PHOTOCHEMISTRY; CYCLOADDITION; NANOPARTICLES; CYCLOOCTYNES |
| Description | The non-catalyzed cycloaddition of eight structurally different azides with cyclooctyne generated in situ by the photolysis of cycloocta-1,2,3- selenadiazole gives 1,2,3-triazole derivatives as the main products. The application of this reaction was demonstrated by the photoconjugation reaction of cycloocta-1,2,3-selenadiazole with an avidin-modified biotin complex to introduce a new strategy in the non-catalyzed synthesis of bioconjugates. |
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