On-line capillary electrophoretic method for kinetic and inhibition studies of beta-secretase

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Authors

ŘEMÍNEK Roman SLEZÁČKOVÁ Lucie SCHEJBAL Jan GLATZ Zdeněk

Year of publication 2016
Type Article in Proceedings
Conference CECE 2016
MU Faculty or unit

Faculty of Science

Citation
Web http://www.ce-ce.org/CECE2016/Proceedings%20CECE%202016_WOS.pdf
Field Analytic chemistry
Keywords kinetics; enzyme; MALDI; BACE; mass spectrometry; inhibice
Description Alzheimer’s disease (AD) represents the most common cause of dementia. According to amyloid cascade hypothesis, pathogenesis of the disease could be slowed down or even stopped by inhibition of beta-secretase. On-line capillary electrophoretic methods represent a promising tool for screening of the enzyme’s activity. A generic on-line CE method for kinetic and inhibition studies of BACE was therefore introduced.
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