Účinná imunoterapie glioblastomu u adolescenta se syndromem konstitučního deficitu v mismatch repair opravném systému
| Title in English | Effective Immunotherapy of Glioblastoma in an Adolescent with Constitutional Mismatch Repair-Deficiency Syndrome |
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| Authors | |
| Year of publication | 2019 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie |
| MU Faculty or unit | |
| Citation | |
| Web | http://dx.doi.org/10.14735/amko201970 |
| Doi | http://dx.doi.org/10.14735/amko201970 |
| Keywords | hereditary cancer predisposition syndromes; glioblastoma; whole exome sequencing; immunotherapy; vaccines; checkpoint inhibitors |
| Description | Individuals with constitutional mismatch repair-deficiency syndrome (CMMR-D) are characterised by early occurrence of colon cancer, haematological malignancies, and brain tumors (malignant gliomas, high-grade gliomas) in childhood, adolescence, and early adulthood. High mutational tumor burden is typical of glioblastoma in CMMR-D patients and could be a reason why this type of glioblastoma responds well to immunotherapies, including those that employ checkpoint inhibitors. |
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