Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates
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| Year of publication | 2021 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
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| Description | Histone deacetylases (HDACs) have been long linked with tumor progression, demonstrating their important role in neoplasia. Inhibitors of HDAC (HDACI), which form a complex with Zn2+ ions in the active site of enzymes, are novel anticancer agents that induce tumor cell death, differentiation, and/or cell cycle arrest. We have designed and synthesized a series of N-hydroxycinnamamide derivates based on common HDAC`s pharmacophore with diversely substituted anilides. |
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