Povrchové markery leukemických kmenových buněk u chronické myeloidní leukemie

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Title in English Leukemic stem cell surface markers in chronic myeloid leukaemia
Authors

SMITALOVÁ Dagmar JEŽÍŠKOVÁ Ivana MAYER Jiří ŽÁČKOVÁ Daniela ČULEN Martin

Year of publication 2023
Type Article in Periodical
Magazine / Source Transfuze a hematologie dnes
MU Faculty or unit

Faculty of Medicine

Citation
Web https://redakce.carecomm.cz/tahd/article/view/1334
Doi http://dx.doi.org/10.48095/cctahd2023prolekare.cz2
Keywords chronic myeloid leukaemia; leukemic stem cells; leukemic stem cell markers
Attached files
Description Treatment with tyrosine kinase inhibitors has revolutionized the management of CML, but only ~ 40% of patients achieve treatment-free remission. One of the underlying causes is persistent leukemic stem cells (LSCs) which are resistant to therapy and survive in quiescent form in the bone marrow niche. This LSC pool can serve as a source of CML reoccurrence and mutation acquisition, which can lead to treatment resistance and disease relapse. Thus, the ideal therapy goal is complete disease eradication including the LSCs. However, specific therapeutic targets are lacking, and even monitoring of these rare cells is problematic. Therefore, there has been intense research to find specific LSC markers which would allow distinction of LSCs from normal stem cells, description of LSC bio logy, and identification of potential therapeutic targets. This article reviews recent studies and clinical trials involving the problems of surface LSC markers in CML.
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