Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Chirality |
| MU Faculty or unit | |
| Citation | |
| Field | Organic chemistry |
| Keywords | spectral non-equivalence; piperidines; NMR; paroxetine |
| Description | S-Mosher acid induced chemical-shift non-equivalence in NMR spectra of chiral trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines. The magnitude of Dd in 1H and 19F NMR spectra varied with the substituent at position 3 of the piperidine ring. The magnitudes Dd observed for certain protons and for the fluorine in the 4-fluorophenyl group were sufficiently large to allow determination of enantiomeric composition. |
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