Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Magnetic Resonance in Chemistry |
| MU Faculty or unit | |
| Citation | |
| Field | Organic chemistry |
| Keywords | NMR; 13C satellites; chemical-shift anisochrony; piperidines; paroxetine; |
| Description | The chemical shift anisochrony of the fluorine signal for the enantiomerically enriched (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine was induced in the presence of S-Mosher acid and its magnitude varied with the enantiomeric purity of 1a. Very low quantities of an enantiomeric impurity 1b, ranging typically from 0.2 to 1%, were evaluated by comparing peak areas of 1b with those of 13C satellite signals that were deconvoluted using an automatic Lorentzian line fitting. |
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