Trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines: Chiral recognition and Transformations

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Authors

NAVRÁTILOVÁ Hana POTÁČEK Milan

Year of publication 2002
Type Article in Proceedings
Conference Book of Abstracts from the 14th International Symposium on Chirality
MU Faculty or unit

Faculty of Science

Citation
Field Organic chemistry
Keywords chiral recognition; microwave irradiation; racemization;
Description The title compounds 2 (Z = OH, Cl, Br, OCH3, mesyl, tosyl, 3,4-(methylenedioxy)phenoxy) are synthetic precursors of an antidepressive drug paroxetine 1 [1]. Chiral recognition of 2 was observed by NMR spectroscopy in the presence of (S)-Mosher acid 5. For most substrates in the series, the non-equivalence induced in their 1H and 19F NMR spectra was sufficiently large to allow the evaluation of enantiomeric purity [2].
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