The role of different 5-HT2 receptor ligands in the mediation of methamphetamine reward properties

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Authors	NOVÁKOVÁ Jana
Year of publication	2003
Type	Article in Periodical
Magazine / Source	Behavioural Pharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	5-HT2 receptor ligands; methamphetamine; reward properties
Description	Our results indicate that only non-selective blockade of 5-HT2A/2B/2C receptors leaded to suppression of rat methamphetamine intake while their stimulation produced no changes. These data correspond with other findings that 5-HT2 receptor antagonists attenuate the expression of alcohol and opiate withdrawal syndrome, and also diminish discriminative-stimulus effects of d-amphetamine.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems