Enhancement of toxicity of selected POPs and its mixtures in consequence of interaction with dissolved organic matter

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Authors	BITTNER Michal MACÍKOVÁ Petra GIESY John P.
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	In waters, dissolved organic matter (DOM) is ubiquitous mixture of individual organic compounds, and humic substances (HS, about 70 % of DOM) that are products of humification process that forms HS from dead organic matter. In our previous in vitro study, we described the interaction (positive or negative) of various DOM/HS samples with aryl hydrocarbon receptor (AhR, also known as dioxin receptor). In this paper, we summarize our new findings on interaction of both AhR-active and -inactive DOM/HS with various persistent organic pollutants (POPs), such as polychlorinated biphenyls, polychlorinated dioxin and polycyclic aromatic hydrocarbons, and their mixtures. Results have shown mostly enhancement or no change of AhR-mediated activity of POPs if co-exposed with DOM/HS. Possible interpretation of the observed results will be discussed. This research has been supported by project GAČR 525/08/P464.
Related projects:	Interaction of humic substances and UV-VIS irradiation with dioxin-like environmental pollutants