HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction

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Authors

POLANSKÁ Eva DOBŠÁKOVÁ Zuzana DVOŘÁČKOVÁ Martina FAJKUS Jiří ŠTROS Michal

Year of publication 2012
Type Article in Periodical
Magazine / Source Chromosoma
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://link.springer.com/article/10.1007%2Fs00412-012-0373-x
Doi http://dx.doi.org/10.1007/s00412-012-0373-x
Field Genetics and molecular biology
Keywords REPEAT AMPLIFICATION PROTOCOL; CHROMOSOMAL-PROTEIN HMG1; DNA-DAMAGE; CHROMATIN; MAINTENANCE; BINDING; EXPRESSION; COMPLEXES; GENOME; GROWTH
Description Telomere repeats are added onto chromosome ends by telomerase, consisting of two main core components: a catalytic protein subunit (telomerase reverse trancriptase, TERT), and an RNA subunit (telomerase RNA, TR). The ability of HMGB1 to modulate cellular activity of telomerase and to maintain telomere integrity can help to understand some aspects of the protein involvement in chromosome stability and cancer.
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