HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction

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Authors	POLANSKÁ Eva DOBŠÁKOVÁ Zuzana DVOŘÁČKOVÁ Martina FAJKUS Jiří ŠTROS Michal
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Chromosoma
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://link.springer.com/article/10.1007%2Fs00412-012-0373-x
Doi	http://dx.doi.org/10.1007/s00412-012-0373-x
Field	Genetics and molecular biology
Keywords	REPEAT AMPLIFICATION PROTOCOL; CHROMOSOMAL-PROTEIN HMG1; DNA-DAMAGE; CHROMATIN; MAINTENANCE; BINDING; EXPRESSION; COMPLEXES; GENOME; GROWTH
Description	Telomere repeats are added onto chromosome ends by telomerase, consisting of two main core components: a catalytic protein subunit (telomerase reverse trancriptase, TERT), and an RNA subunit (telomerase RNA, TR). The ability of HMGB1 to modulate cellular activity of telomerase and to maintain telomere integrity can help to understand some aspects of the protein involvement in chromosome stability and cancer.
Related projects:	Telomeres and telomerase: transition from molecular to structural biology approach CEITEC - Central European Institute of Technology Proteiny HMGB: funkce v biologii telomer a lidských embryonálních kmenových buněk