All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	SARYCHEVA Tatyana Vladimirovna CAPKOVA Nadezda PAJAK Andrzej MALYUTINA Sofia TAMOSIUNAS Abdonas BOBÁK Martin PIKHART Hynek
Rok publikování	2022
Druh	Článek v odborném periodiku
Časopis / Zdroj	Nature Scientific Reports
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
www	https://www.nature.com/articles/s41598-022-17261-5
Doi	http://dx.doi.org/10.1038/s41598-022-17261-5
Klíčová slova	PULMONARY-FUNCTION; INCREASED RISK; FEV1; SPIROMETRY; PREDICTOR; INDIVIDUALS; ASSOCIATION; OUTCOMES; VALUES
Přiložené soubory	2218237.pdf
Popis	It is unclear whether the dose-response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean age of 59 +/- 7.3 years from population registers in Czech, Polish, Russian and Lithuanian urban centres. The baseline survey in 2002-2005 included 36,106 persons of whom 24,944 met the inclusion criteria. Cox proportional hazards models were used to estimate the dose-response relationship between lung function defined as FEV1 divided by height cubed and all-cause and cardiovascular mortality over 11-16 years of follow-up. Mortality rate increased in a dose-response manner from highest to lower FEV1/height(3) deciles. Adjusted hazard ratios (HR) of all-cause mortality for persons in the 8th best, the 5th and the worst deciles were 1.27 (95% CI 1.08-1.49), 1.37 (1.18-1.60) and 2.15 (1.86-2.48), respectively; for cardiovascular mortality, the respective HRs were 1.84 (1.29-2.63), 2.35 (1.67-3.28) and 3.46 (2.50-4.78). Patterns were similar across countries, with some statistically insignificant variation. FEV1/height(3) is a strong predictor of all-cause and cardiovascular mortality, across full distribution of values, including persons with preserved lung function.
Související projekty:	R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research CETOCOEN Excellence CETOCOEN Excellence Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění