Informace o projektu
The national infrastructure C4SYS - Centre for Systems Biology
(C4SYS)
- Kód projektu
- LM2015055
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
- Další fakulta/pracoviště MU
- Fakulta informatiky
- Spolupracující organizace
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Mikrobiologický ústav AV ČR, v. v. i.
Jihočeská univerzita v Českých Budějovicích
Centrum výzkumu globální změny AV ČR, v. v. i.
The national infrastructure C4SYS - Centre for Systems Biology is a priority infrastructure project on the national roadmap, and currently in its preparatory phase, building on close collaboration between the Academy of Sciences (Institute of Microbiology, Prague, Institute of Nanobiology and Structural Biology, Nove Hrady, Global Change Research Center, Brno), the University of South Bohemia, and Masaryk University, Brno. It has the ambition to concentrate the knowledge potential in the field of systems biology in the Czech Republic and to connect the diverted systems biology research at the Academy of Sciences and various universities in the Czech Republic to the european infastructure (ISBE). C4SYS will enable Czech ad European laboratories to model, conduct experiments and proceed other activities, where they cannot be done locally, but which are required for their systems biology research. This virtual platform is providing the research community resources and services for the implementation of cutting-edge research and development internationally. This is an essential point because Systems Biology requires significantly more multidisciplinary facilities and international access than are typically present in any single institute. The infrastructure was initiated in 2009 as a divison of the former Institute of Systems Biology and Ecology of the Academy of Sciences of the Czech Republic, and became part of the Czech roadmap as a promising project in the 2010 update, and a high-priority project in the 2011 update. In 2014 the above mentioned institutions signed a memorandum of understanding, that finalizes the preparatory phase and initiates the construction phase that is planned for 2015-2017.
Publikace
Počet publikací: 71
2019
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Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase
Proceedings of the National Academy of Sciences of the United States of America, rok: 2019, ročník: 116, vydání: 2, DOI
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Fast Screening of Inhibitor Binding/Unbinding using Novel Software Tool CaverDock
FRONTIERS IN CHEMISTRY, rok: 2019, ročník: 7, vydání: OCT 29 2019, DOI
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In vitro bioaccessibility of selenoamino acids from selenium (Se)-enriched Chlorella vulgaris biomass in comparison to selenized yeast; a Se-enriched food supplement; and Se-rich foods
Food Chemistry, rok: 2019, ročník: 279, vydání: May, DOI
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Noninvasive determination of toxic stress biomarkers by high-throughput screening of photoautotrophic cell suspension cultures with multicolor fluorescence imaging
PLANT METHODS, rok: 2019, ročník: 15, vydání: 1, DOI
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Quantitative Conformational Analysis of Functionally Important Electrostatic Interactions in the Intrinsically Disordered Region of Delta Subunit of Bacterial RNA Polymerase
Journal of the American Chemical Society, rok: 2019, ročník: 141, vydání: 42, DOI
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Structure-Function Relationships and Engineering of Haloalkane Dehalogenases
Aerobic Utilization of Hydrocarbons, Oils, and Lipids, rok: 2019, počet stran: 21 s.
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Transhalogenation Catalysed by Haloalkane Dehalogenases Engineered to Stop Natural Pathway at Intermediate
ADVANCED SYNTHESIS & CATALYSIS, rok: 2019, ročník: 361, vydání: 11, DOI
2018
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A residue of motif III positions the helicase domains of motor subunit HsdR in restriction-modification enzyme EcoR124I
JOURNAL OF MOLECULAR MODELING, rok: 2018, ročník: 24, vydání: 7, DOI
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Advancement of the cultivation and upscaling of photoautotrophic suspension cultures using Chenopodium rubrum as a case study
Plant Cell, Tissue and Organ Culture, rok: 2018, ročník: 135, vydání: 1, DOI
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CalFitter: a web server for analysis of protein thermal denaturation data
Nucleic Acids Research, rok: 2018, ročník: 46, vydání: W1, DOI